NIH Epub 2013 Sep 25.  |  Reverse cholesterol transport (RCT) is the process of cholesterol movement from the extrahepatic tissues back to the liver. Epub 2015 Jan 14. Compared with other lipoproteins, they have thehighest relative density while being smallest in size. NCI CPTC Antibody Characterization Program, Smith LC, Pownall HJ, Gotto AM., Jr The plasma lipoproteins: structure and metabolism. 2018 Jul;38(7):1454-1467. doi: 10.1161/ATVBAHA.118.311056. Nuclear receptors of the RXR heterodimer family have recently been shown to regulate key genes involved in HDL metabolism and reverse cholesterol transport. Reverse cholesterol transport refers to the process by which cholesterol is removed from the tissues and returned to the liver. Strong experimental evidence confirms that HDL directly alleviates atherosclerosis. Lipoproteins containing apoA-I [high-density lipoprotein (HDL)] are key mediators in RCT, whereas non-high-density lipoproteins (non-HDL, lipoproteins containing apoB) are involved in the lipid delivery pathway. 2003 Dec;33(12):1051-69. doi: 10.1111/j.1365-2362.2003.01263.x. Cholesterol from non-hepatic peripheral tissues is transferred to HDL by the ABCA1 ( ATP-binding cassette transporter ). National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error.  |  1978;47:751–7. Early pregnancy serum IGFBP-1 relates to lipid profile in overweight and obese women. Arterioscler Thromb Vasc Biol. In vivo macrophage-specific RCT and antioxidant and antiinflammatory HDL activity measurements: New tools for predicting HDL atheroprotection. The cardioprotective role of HDL is thought to be related at least in part to the role of HDL in reverse cholesterol transport (RCT), the process by which cholesterol is removed from peripheral cells and transported to the liver for metabolism and excretion in the bile [ 13, 14 ]. Int J Mol Sci. 2020 Oct 14;21(20):7606. doi: 10.3390/ijms21207606. 2020 Dec;27(1):530-541. doi: 10.1080/10717544.2020.1745330. 2020 Aug 30;21(17):6275. doi: 10.3390/ijms21176275. NLM Progress in our understanding of HDL metabolism and macrophage reverse cholesterol transport will increase the likelihood of developing novel therapies to raise plasma HDL concentrations and promote macrophage RCT and in proving that these new therapeutic interventions prevent or cause regression of atherosclerosis in humans. Alterations in high-density lipoprotein metabolism and reverse cholesterol transport in insulin resistance and type 2 diabetes mellitus: role of lipolytic enzymes, lecithin:cholesterol acyltransferase and lipid transfer proteins. LXR-induced redistribution of ABCG1 to plasma membrane in macrophages enhances cholesterol mass efflux to HDL. Affiliations. Apolipoprotein A-II is a key regulatory factor of HDL metabolism as appears from studies with transgenic animals and clinical outcomes. The second theme is the critical role that intravascular remodeling of HDL by lipid transfer factors, lipases, cell surface receptors, and non-HDL lipoproteins play in determining the ultimate metabolic fate of HDL and plasma HDL-c concentrations. Targeting HDL Metabolism and Reverse Cholesterol Transport. -. Reverse cholesterol transport (RCT) is the process of cholesterol movement from the extrahepatic tissues back to the liver. 2009 Oct;206(2):321-7. doi: 10.1016/j.atherosclerosis.2008.12.044. A cell cannot metabolize cholesterol to energy theway it the transport of cholesterol from peripheral cells back to the liver for metabolism and biliary excretion, in insulin resistance and type 2 diabetes mellitus. Wang N, Lan D, Chen W, Matsuura F, Tall AR. HDL particles display diverse atheroprotective functions in reverse cholesterol transport (RCT), antioxidant, anti-inflammatory, and antiapoptotic processes. The individual lipid and apolipoprotein components of HDL are mostly assembled after secretion, are frequently exchanged with or transferred to other lipoproteins, are actively remodeled within the plasma compartment, and are often cleared separately from one another. HDL are heterogeneous particles regarding their sizeand composition. Millar et al. M01 RR00040/RR/NCRR NIH HHS/United States. Int J Mol Sci. A key to effective treatment of cardiovascular disease is to understand the body's complex lipoprotein transport system. This review describes abnormalities in HDL metabolism and reverse cholesterol transport, i.e. Meng Q, Pu L, Luo X, Wang B, Li F, Liu B. 96.3.2 High-Density Lipoprotein (HDL) Metabolism “ Reverse cholesterol transport ” (RCT) describes cholesterol transport in HDL from peripheral cells back to the liver for secretion in bile (17). Lipoproteins containing apoA-I [highdensity lipoprotein (HDL)] are key mediators in RCT, whereas non-high-density lipoproteins (non-HDL, lipoproteins containing apoB) are involved in the lipid delivery pathway. Simplified model of Reverse Cholesterol Transport -HDL is made in the blood from Apo A1 that is secreted from the liver -ApoA1 responds to lipid rich meal -ApoA1 forms a pre beta HDL particle (should be more of a flattened shape; it's nascent) HDL is believed to play a key role in the process of reverse cholesterol transport (RCT), in which it promotes the efflux of excess cholesterol from peripheral tissues and returns it to the liver for biliary excretion. Furthermore, thermogenic stimulation promotes HDL-cholesterol clearance and increases macrophage-to-faeces reverse cholesterol transport in mice. N Engl J Med. J Mol Med (Berl). Elucidations of HDL metabolism give rise to therapeutic targets wit h po-tential to raising plasma HDL cholesterol levels, thereby reducing the risk of developing CHD. High-Density Lipoprotein (HDL) in Allergy and Skin Diseases: Focus on Immunomodulating Functions. Proc Natl Acad Sci U S A. Hepatic Overexpression of Endothelial Lipase Lowers High-Density Lipoprotein but Maintains Reverse Cholesterol Transport in Mice: Role of Scavenger Receptor Class B Type I/ATP-Binding Cassette Transporter A1-Dependent Pathways. 2006 Apr;84(4):276-94. doi: 10.1007/s00109-005-0030-4.  |  Epub 2009 Jan 19. Escolà-Gil JC, Rotllan N, Julve J, Blanco-Vaca F. Atherosclerosis. Lipoproteins containing apoA-I [high- density lipoprotein (HDL)] are key mediators in RCT, whereas non-high-density lipoproteins (non-HDL, lipoproteins containing apoB) are involved in the lipid delivery pathway. Results of clinical trials should be awaited before further clinical management of atherosclerotic cardiovascular disease. Takiguchi S, Ayaori M, Yakushiji E, Nishida T, Nakaya K, Sasaki M, Iizuka M, Uto-Kondo H, Terao Y, Yogo M, Komatsu T, Ogura M, Ikewaki K. Arterioscler Thromb Vasc Biol. 2005;352:1685–95. Dash R, Ali MC, Rana ML, Munni YA, Barua L, Jahan I, Haque MF, Hannan MA, Moon IS. HDL helps in reverse cholesterol transport from extrahepatic tissues to the liver. Mechanistically, we show that intravascular lipolysis by adipocyte lipoprotein lipase and hepatic uptake of HDL by scavenger receptor B-I are the driving forces of HDL-cholesterol disposal in liver. One area of agreement is that reverse cholesterol transport remains a primary hypothesis for an anti-atherogenic role of HDL. Clipboard, Search History, and several other advanced features are temporarily unavailable.  |  Reverse cholesterol transport in type 2 diabetes mellitus. The Framingham Study. 2 authors. Wang N, Ranalletta M, Matsuura F, Peng F, Tall AR. Du XM, Kim MJ, Hou L, Le Goff W, Chapman MJ, Van Eck M, Curtiss LK, Burnett JR, Cartland SP, Quinn CM, Kockx M, Kontush A, Rye KA, Kritharides L, Jessup W. Circ Res. USA.gov. 2006 Jun;26(6):1310-6. doi: 10.1161/01.ATV.0000218998.75963.02. J Biomed Res. In this video, I have explained HDL synthesis as a nascent HDL and maturation of HDL. Circulation. Please enable it to take advantage of the complete set of features! Nature. HHS C, cholesterol; CE, cholesteryl ester; LCAT, lecithin cholesterol ethyl transferase; PL, phospholipid; ApoA-1, apolipoprotein A-1. HDL in the high (if not the “extremely high”) range usually correlates with efficient reverse cholesterol transport and has benefits for cardiovascular health, inflammation, antioxidant status etc, but people with HDL outside (higher or lower than) the ideal range can be equally healthy if their overall metabolic health (insulin sensitivity) is good.  |  Epub 2006 Mar 23. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. This review will emphasize 3 major evolving themes regarding HDL metabolism and RCT. 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